I think the members of this forum are probably biased. That said,
Without having seen the Accord or even a review; I suspect that the Accord rides and handles better, gets slightly worse gas mileage, and is slightly less "green" (low emissions.) I don't know what the balance is on the "gadget" factor (bluetooth, nav, etc.) For me, the fact that the Prius is a hatch back was important, I use it to haul awkward stuff around fairly often.
You have to balance the pros and cons with your priorities.