I've been using Mobil 1 in my Prius since the beginning. Synthetic oil may be over hyped as to some of its benefits, but it is a quality product and I don't regret using it. I do think that pure Synthetics may have greater detergent levels in them, thus trapping dirt and impurities better than conventional oils, but beyond that, so long as you use the proper weight of oil in your vehicle and change it on the more frequent maintenance schedule specified by the manufacturer, you should be just fine.
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